Published Works

Books by Sheldon Barnes

Three books at the intersection of artificial intelligence, enterprise leadership, and the modern career landscape.

The Platform Inversion book cover

The Platform Inversion

Leading AI-First Engineering Teams from Point Solutions to Intelligent Operating Platforms

The operating model for senior engineering leaders who need to move beyond coding assistants and build intelligent platforms that compound value. Written for directors, VPs, and staff-plus engineers in regulated industries.

The Digital Work Equivalent (DWE) metric
Six-layer AI-First operating framework
30/60/90 day transformation playbook
The $200 Billion Problem book cover

The $200 Billion Problem

How AI Is Rewriting Drug Discovery and Closing Pharma's Patent Cliff

Between now and 2030, patent protections will expire on drugs generating over $200 billion in annual revenue. This book traces the collision of pharma's greatest financial crisis with the scientific revolution that may be its answer, AI deployed across every stage of how drugs are discovered and developed.

The Prediction Stack — a three-layer framework for understanding drug discovery failure
AI across the full pipeline: target ID, molecule design, digital twins, clinical trials
Platform companies changing the game: Recursion, Insilico, Isomorphic Labs
Why You're Not Getting Hired book cover

Why You're Not Getting Hired

The Hidden System Filtering You Out — and How to Beat It

The hiring process was redesigned by AI and nobody told the candidates. This field manual pulls back the curtain on Applicant Tracking Systems, algorithmic scoring, and AI-powered screening, then gives you a repeatable system to beat them.

The Resume Match Score (RMS) — measure how well your resume maps to any job description
The Role Fit Score (RFS) — evaluate if a job is right for you before optimizing for it
How ATS platforms parse, score, and filter your application